An aggregation-induced emission-based pH-sensitive fluorescent probe for intracellular acidity sensing

Na Lin; Xiaohong Chen; Shuanghong Yan; Han Wang; Zhixiang Lu; Xin Xia; Mengyu Liang; Yun-Long Wu; Liyan Zheng; Qiue Cao; Zhongtao Ding

doi:10.1039/C6RA01167E

An aggregation-induced emission-based pH-sensitive fluorescent probe for intracellular acidity sensing†‡

Na Lin,^a Xiaohong Chen,^b Shuanghong Yan,^a Han Wang,^b Zhixiang Lu,^a Xin Xia,^a Mengyu Liang,^a Yun-Long Wu,*^b Liyan Zheng,*^a Qiue Cao*^a and Zhongtao Ding^a

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^a Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, Yunnan 650091, P. R. China
E-mail: zhengliyan@ynu.edu.cn, qecao@ynu.edu.cn

^b School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, P. R. China
E-mail: wuyl@xmu.edu.cn

Abstract

A dual-emission pH-sensitive fluorescent probe was developed, which displays green fluorescence in alkaline after deprotonation, while orange emission in acid at aggregated state. This novel probe allows the specific light-on in acidic lysosomes of cancer cells and tumors in nude mice, which indicates its potential application in cancer diagnosis.

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An aggregation-induced emission-based pH-sensitive fluorescent probe for intracellular acidity sensing†‡

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An aggregation-induced emission-based pH-sensitive fluorescent probe for intracellular acidity sensing

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