Issue 19, 2016
From the journal:

RSC Advances

Solvent strategy for unleashing the Lewis acidity of titanocene dichloride for rapid Mannich reactions†

Ya Wu,ab   Xiu Wang,a   Yanlong Luo,a   Jing Wang,a   Yajun Jian,a   Huaming Sun,a   Guofang Zhang,a   Weiqiang Zhang*a  and  Ziwei Gao*a  

* Corresponding authors

a Key Laboratory of Applied Surface and Colloid Chemistry, MOE, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710062, China
E-mail: zwgao@snnu.edu.cn
Fax: +86-29-81530727

b College of Chemistry and Chemical Engineering, Xi'an Shiyou University, Xi'an 710065, P. R. China

Abstract

The remarkable activation effect of alcohol solvent on kinetically inert titanocene dichloride was found to promote rapid three-component Mannich reactions. NMR and ESI-MS analyses as well as a control experiment of catalytic active species elucidated that the coordination of MeOH to the titanocene moiety unleashed the Lewis acid [Cp2Ti(OMe)2] and Brønsted acid HCl, which led to the enhanced catalytic activity of [Cp2TiCl2].

Graphical abstract: Solvent strategy for unleashing the Lewis acidity of titanocene dichloride for rapid Mannich reactions

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Article information

DOI
https://doi.org/10.1039/C5RA27094D
Article type
Communication
Submitted
18 Dec 2015
Accepted
12 Jan 2016
First published
21 Jan 2016

RSC Adv., 2016,6, 15298-15303

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Solvent strategy for unleashing the Lewis acidity of titanocene dichloride for rapid Mannich reactions

Y. Wu, X. Wang, Y. Luo, J. Wang, Y. Jian, H. Sun, G. Zhang, W. Zhang and Z. Gao, RSC Adv., 2016, 6, 15298 DOI: 10.1039/C5RA27094D

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