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Issue 28, 2016
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Synthesis and in vivo stability studies of [18F]-zwitterionic phosphonium aryltrifluoroborate/indomethacin conjugates

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Abstract

With the goal of developing new positron emission tomography (PET) probes for imaging inflammation in cancer tumours, we have conjugated zwitterionic phosphonium aryltrifluoroborates as fluoride captors with indomethacin, a known cyclooxygenase 2 inhibitor. The resulting conjugates have been radiolabeled by 18F–19F isotopic exchange in aqueous solutions. NMR studies combined with in vivo data show that the nature of the phosphonium substituents plays an important role on the stability of the radiotracers.

Graphical abstract: Synthesis and in vivo stability studies of [18F]-zwitterionic phosphonium aryltrifluoroborate/indomethacin conjugates

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Publication details

The article was received on 09 Dec 2015, accepted on 02 Feb 2016 and first published on 02 Feb 2016


Article type: Paper
DOI: 10.1039/C5RA26323A
RSC Adv., 2016,6, 23126-23133

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    Synthesis and in vivo stability studies of [18F]-zwitterionic phosphonium aryltrifluoroborate/indomethacin conjugates

    K. Chansaenpak, M. Wang, S. Liu, Z. Wu, H. Yuan, P. S. Conti, Z. Li and F. P. Gabbaï, RSC Adv., 2016, 6, 23126
    DOI: 10.1039/C5RA26323A

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