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Issue 12, 2016
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Cross-species biosynthesis of maytansine in Maytenus serrata

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Abstract

Endophytic bacterial communities harboring different tissues of Maytenus serrata originating from Cameroon were investigated using targeted genome mining techniques coupled to bioanalytical approaches to elucidate the source of maytansine biosynthesis. It was revealed that the host plant, along with its cryptic endophytic microflora, produces the biosynthetically unique core structural moiety 3-amino-5-hydroxybenzoic acid (AHBA) that serves as the unique starter unit for maytansine biosynthesis. However, the biosynthetic step of halogenase-mediated incorporation of chlorine, which is missing in the host plant, is accomplished by the culturable stem endophytic bacterial community. Our results provide new insights into plant-endophyte communication for the biosynthesis of maytansine.

Graphical abstract: Cross-species biosynthesis of maytansine in Maytenus serrata

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Publication details

The article was received on 25 Nov 2015, accepted on 15 Jan 2016 and first published on 18 Jan 2016


Article type: Communication
DOI: 10.1039/C5RA25042K
RSC Adv., 2016,6, 10011-10016
  • Open access: Creative Commons BY-NC license
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    Cross-species biosynthesis of maytansine in Maytenus serrata

    P. Kusari, S. Kusari, D. Eckelmann, S. Zühlke, O. Kayser and M. Spiteller, RSC Adv., 2016, 6, 10011
    DOI: 10.1039/C5RA25042K

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