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Issue 7, 2016
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Assessment of polydopamine coated magnetic nanoparticles in doxorubicin delivery

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Abstract

Magnetic nanoparticles (MNP) coated with bioinspired polydopamine (PDA) were obtained via a co-precipitation method and oxidative polymerization of dopamine. Nanoparticles were investigated by FTIR, TEM and SQUID. Loading capacity of anticancer drug doxorubicin was determined by UV-Vis spectroscopy. The nanocomposites exhibit a high drug loading capacity of 0.46 mg mg−1. Anticancer activity of the nanocomposites was proved in profound in vitro tests on HeLa cells. Cytotoxicity and internalization of nanoparticles were checked using various method, i.e. proliferation assay (WST-1), a two-colour fluorescence cell viability assay, and fluorescent and confocal microscopy.

Graphical abstract: Assessment of polydopamine coated magnetic nanoparticles in doxorubicin delivery

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Supplementary files

Article information


Submitted
16 Nov 2015
Accepted
05 Jan 2016
First published
08 Jan 2016

RSC Adv., 2016,6, 5936-5943
Article type
Paper

Assessment of polydopamine coated magnetic nanoparticles in doxorubicin delivery

R. Mrówczyński, J. Jurga-Stopa, R. Markiewicz, E. L. Coy, S. Jurga and A. Woźniak, RSC Adv., 2016, 6, 5936
DOI: 10.1039/C5RA24222C

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