Issue 35, 2016
From the journal:

RSC Advances

Carbon nano onions cross the blood brain barrier†

Bholanath Pakhira,ad   Mitrajit Ghosh,b   Afreen Allamc  and  Sabyasachi Sarkar*a  

* Corresponding authors

a Nano Science and Synthetic Leaf Laboratory, Centre for Healthcare Science and Technology, Indian Institute of Engineering Science and Technology, Shibpur, Botanic Garden-711103, Howrah, West Bengal, India
E-mail: abya@iitk.ac.in

b Institute for Stroke and Dementia Research (ISD) and Munich Cluster for System, Neurology (Synergy), University of Munich, Medical Centre, Munich-81377, Germany

c Cromoz. Inc. 2 Davis Drive, Research Triangle Park, NC-27709, USA

d Dept. of Chemistry, Sister Nibedita Govt. General Degree College for Girls, Hastings House, Alipore, Kolkata 700027, India

Abstract

We show the crossing of small sized water soluble fluorescent carbon nano onion (wsCNO) through the blood brain barrier (BBB) in the Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) murine model as well as in glioblastoma multiforme (GBM) induced mice. It is readily excreted from the body after a few days suggesting its possible use as cargo in drug delivery.

Graphical abstract: Carbon nano onions cross the blood brain barrier

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Article information

DOI
https://doi.org/10.1039/C5RA23534K
Article type
Communication
Submitted
08 Nov 2015
Accepted
16 Mar 2016
First published
17 Mar 2016

RSC Adv., 2016,6, 29779-29782

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Carbon nano onions cross the blood brain barrier

B. Pakhira, M. Ghosh, A. Allam and S. Sarkar, RSC Adv., 2016, 6, 29779 DOI: 10.1039/C5RA23534K

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