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Issue 2, 2016
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An electronic platform for real-time detection of bovine serum albumin by means of amine-functionalized zinc oxide microwires

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Abstract

We report the fabrication of a customized electronic platform for biosensing, integrating a single functionalized microwire between gold microelectrodes as a sensing element, including a custom microelectronic chip for signal readout. As a proof-of-concept, the platform was validated for the real-time detection of Bovine Serum Albumin (BSA) binding onto an NH2-functionalized zinc oxide (ZnO-NH2) microwire. The ZnO-NH2 microwires were deposited between two gold electrodes by means of a dielectrophoresis (DEP) technique. A Quasi-Digital Impedance Converter (QDIC) was conceived to constantly and instantaneously readout ZnO microwire impedance and transfer data to a laptop. Microelectrodes, a QDIC, a DEP generator, and data analysis were integrated in a stacked-card PCB configuration for a better noise reduction and usability. The system was able to distinguish between different BSA concentrations and to give real-time information about the binding process.

Graphical abstract: An electronic platform for real-time detection of bovine serum albumin by means of amine-functionalized zinc oxide microwires

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Publication details

The article was received on 06 Aug 2015, accepted on 02 Dec 2015 and first published on 07 Dec 2015


Article type: Paper
DOI: 10.1039/C5RA15787K
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RSC Adv., 2016,6, 891-897

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    An electronic platform for real-time detection of bovine serum albumin by means of amine-functionalized zinc oxide microwires

    A. Sanginario, V. Cauda, A. Bonanno, K. Bejtka, S. Sapienza and D. Demarchi, RSC Adv., 2016, 6, 891
    DOI: 10.1039/C5RA15787K

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