Jump to main content
Jump to site search

Issue 12, 2016
Previous Article Next Article

Rh(i)-Catalyzed coupling of 2-bromoethyl aryldiazoacetates with tertiary propargyl alcohols through carbene migratory insertion

Author affiliations

Abstract

A Rh(I)-catalyzed cross-coupling of 2-bromoethyl aryldiazoacetates with tertiary propargyl alcohols has been successfully achieved. This reaction follows a reaction sequence which involves C–C bond cleavage, Rh(I) carbene formation, carbene migratory insertion and nucleophilic substitution to achieve the construction of C(sp2)–C(sp) and C–O bonds. The products feature both enyne and ketene acetal moieties, which have been widely used as building blocks in organic synthesis and polymer science.

Graphical abstract: Rh(i)-Catalyzed coupling of 2-bromoethyl aryldiazoacetates with tertiary propargyl alcohols through carbene migratory insertion

Back to tab navigation

Supplementary files

Article information


Submitted
11 Aug 2016
Accepted
26 Sep 2016
First published
27 Sep 2016

Org. Chem. Front., 2016,3, 1691-1698
Article type
Research Article

Rh(I)-Catalyzed coupling of 2-bromoethyl aryldiazoacetates with tertiary propargyl alcohols through carbene migratory insertion

Z. Liu, Y. Xia, S. Feng, Y. Zhang and J. Wang, Org. Chem. Front., 2016, 3, 1691
DOI: 10.1039/C6QO00453A

Social activity

Search articles by author

Spotlight

Advertisements