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Issue 9, 2016
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Pd(ii)-catalyzed direct functionalization of C–H bonds of benzamides for synthesis of 1,1-difluoro-1-alkenes

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Abstract

Pd-catalyzed direct difluoroallylation of C–H bonds of benzamides with readily available Rf-Br reagents is reported. The reaction proceeds via Pd-catalyzed C–H activation, followed by reaction of the resulting intermediate with 3-bromo-3,3-difluoropropene (BDFP) in a γ-selective fashion. The C–H functionalization process was characterized by a broad substrate scope as well as an excellent functional-group tolerance.

Graphical abstract: Pd(ii)-catalyzed direct functionalization of C–H bonds of benzamides for synthesis of 1,1-difluoro-1-alkenes

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Supplementary files

Article information


Submitted
28 Apr 2016
Accepted
17 Jun 2016
First published
20 Jun 2016

Org. Chem. Front., 2016,3, 1080-1083
Article type
Research Article

Pd(II)-catalyzed direct functionalization of C–H bonds of benzamides for synthesis of 1,1-difluoro-1-alkenes

C. Li, D. Zhang, W. Zhu, P. Wan and H. Liu, Org. Chem. Front., 2016, 3, 1080
DOI: 10.1039/C6QO00178E

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