An α-regioselective asymmetric [3 + 2] annulation reaction with Morita–Baylis–Hillman carbonates of isatins and (E)-2-nitro-1,3-enynes catalysed by cinchona-derived amines has been developed, providing spirooxindoles with contiguous chiral centres including adjacent quaternary ones in moderate to good yields with high enantioselectivity and excellent diastereoselectivity.
![Graphical abstract: α-Regioselective [3 + 2] annulations with Morita–Baylis–Hillman carbonates of isatins and 2-nitro-1,3-enynes](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C6QO00118A&imageInfo.ImageIdentifier.Year=2016)
G. Ran, P. Wang, W. Du and Y. Chen, Org. Chem. Front., 2016, 3, 861 DOI: 10.1039/C6QO00118A
To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.
If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.
If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.
Read more about how to correctly acknowledge RSC content.
Please wait while we load your content...
