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Issue 7, 2016
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Catalytic asymmetric α-amination of β-keto esters and β-keto amides with a chiral N,N′-dioxide–copper(i) complex

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Abstract

The highly efficient asymmetric α-amination of β-keto esters and β-keto amides was realized by using a chiral N,N′-dioxide/Cu(I) complex. Under mild reaction conditions, a series of corresponding chiral α-amino dicarbonyl compounds were obtained in excellent yields (up to 98%) with excellent enantioselectivities (up to 95% ee).

Graphical abstract: Catalytic asymmetric α-amination of β-keto esters and β-keto amides with a chiral N,N′-dioxide–copper(i) complex

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Article information


Submitted
08 Mar 2016
Accepted
27 Apr 2016
First published
09 May 2016

Org. Chem. Front., 2016,3, 809-812
Article type
Research Article

Catalytic asymmetric α-amination of β-keto esters and β-keto amides with a chiral N,N′-dioxide–copper(I) complex

X. Xiao, L. Lin, X. Lian, X. Liu and X. Feng, Org. Chem. Front., 2016, 3, 809
DOI: 10.1039/C6QO00095A

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