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Issue 3, 2016
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Pd(ii)-catalyzed β-C–H arylation of O-methyl ketoximes with iodoarenes

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Abstract

A Pd(II)-catalyzed selective β-arylation of O-methyl ketoximes was developed using iodoarenes as the coupling partners. This transformation has good functional group compatibility and can serve as a powerful synthetic tool for late-stage C–H arylation of complex compounds. Moreover, when employing 2-iodobenzoic acids as the substrates in this developed catalytic system, a type of unexpected five-membered lactones could be formed by tandem sp3 C–H arylation and oxygenation.

Graphical abstract: Pd(ii)-catalyzed β-C–H arylation of O-methyl ketoximes with iodoarenes

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Supplementary files

Article information


Submitted
24 Dec 2015
Accepted
20 Jan 2016
First published
21 Jan 2016

Org. Chem. Front., 2016,3, 380-384
Article type
Research Article
Author version available

Pd(II)-catalyzed β-C–H arylation of O-methyl ketoximes with iodoarenes

Y. Mu, X. Tan, Y. Zhang, X. Jing and Z. Shi, Org. Chem. Front., 2016, 3, 380 DOI: 10.1039/C5QO00438A

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