Issue 3, 2016

N-Heterocyclic carbene catalyzed dehydrogenative coupling of enals: synthesis of monobactams

Abstract

The first NHC-catalyzed dehydrogenative coupling of enals is described. With a suitable combination of NHC precatalyst, base, and solvent, the reaction proceeded smoothly to yield a wide range of monobactams. These substituted monobactams have been synthesized for the first time, and they are versatile synthetic intermediates toward other useful complex molecules.

Graphical abstract: N-Heterocyclic carbene catalyzed dehydrogenative coupling of enals: synthesis of monobactams

Associated articles

Supplementary files

Article information

Article type
Research Article
Submitted
14 Nov 2015
Accepted
05 Jan 2016
First published
07 Jan 2016

Org. Chem. Front., 2016,3, 335-338

N-Heterocyclic carbene catalyzed dehydrogenative coupling of enals: synthesis of monobactams

F. Li, C. Zhao and J. Wang, Org. Chem. Front., 2016, 3, 335 DOI: 10.1039/C5QO00372E

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