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Issue 5, 2016
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Smart block copolymers of PVP and an alkylated PVP derivative: synthesis, characterization, thermoresponsive behaviour and self-assembly

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Abstract

Stimuli responsive block copolymers of biocompatible poly(3-ethyl-N-vinylpyrrolidone) and poly(N-vinylpyrrolidone), i.e. EPVP–PVP, were readily synthesized via RAFT-mediated polymerization. The thermoresponsive behaviour and temperature induced self-assembly, in aqueous solutions, was studied using various spectroscopic and microscopy techniques. We obtained different morphologies, i.e. spherical and cylindrical micelles, and vesicles, via temperature induced self-assembly, of aqueous solutions of a single diblock copolymer by simply adjusting the solution concentration. This study establishes the biocompatible EPVP/PVP combination as a versatile stimuli responsive block copolymer system suitable for applications in drug delivery.

Graphical abstract: Smart block copolymers of PVP and an alkylated PVP derivative: synthesis, characterization, thermoresponsive behaviour and self-assembly

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Supplementary files

Article information


Submitted
06 Oct 2015
Accepted
22 Dec 2015
First published
23 Dec 2015

Polym. Chem., 2016,7, 1138-1146
Article type
Paper
Author version available

Smart block copolymers of PVP and an alkylated PVP derivative: synthesis, characterization, thermoresponsive behaviour and self-assembly

J. Giliomee, R. Pfukwa, N. P. Gule and B. Klumperman, Polym. Chem., 2016, 7, 1138
DOI: 10.1039/C5PY01609F

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