Jump to main content
Jump to site search

Issue 2, 2016
Previous Article Next Article

Facile production of nanoaggregates with tuneable morphologies from thermoresponsive P(DEGMA-co-HPMA)

Author affiliations

Abstract

Thermoresponsive polymers are used to produce nanoparticles or nanoaggregates for a wide range of applications such as nanomedicine. However, low-toxicity, thermoresponsive polymers such as methacrylate polymers with short oligo(ethylene glycol) side chains are not readily applicable to the synthesis of nanoaggregates with both spherical and nonspherical morphologies. Here we report the synthesis of a low-toxicity, thermoresponsive copolymer, P(DEGMA-co-HPMA), and describe its application in the RAFT-mediated emulsion polymerization of styrene as a means to produce nanoparticles with tuneable morphology (sphere, cylinder, vesicle and lamella). These nanoaggregates offer considerable potential as a novel platform for the next generation of nanotherapeutics with improved efficacy.

Graphical abstract: Facile production of nanoaggregates with tuneable morphologies from thermoresponsive P(DEGMA-co-HPMA)

Back to tab navigation

Supplementary files

Article information


Submitted
11 Sep 2015
Accepted
08 Nov 2015
First published
16 Nov 2015

Polym. Chem., 2016,7, 430-440
Article type
Paper
Author version available

Facile production of nanoaggregates with tuneable morphologies from thermoresponsive P(DEGMA-co-HPMA)

N. P. Truong, M. R. Whittaker, A. Anastasaki, D. M. Haddleton, J. F. Quinn and T. P. Davis, Polym. Chem., 2016, 7, 430
DOI: 10.1039/C5PY01467K

Social activity

Search articles by author

Spotlight

Advertisements