trans- and cis-(Cl,Cl)-[RuII(FT)Cl2(NO)](PF6): promising candidates for NO release in the NIR region

Joelle Akl; Isabelle Sasaki; Pascal G. Lacroix; Vincent Hugues; Patricia Vicendo; Mathilde Bocé; Sonia Mallet-Ladeira; Mireille Blanchard-Desce; Isabelle Malfant

doi:10.1039/C6PP00181E

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trans- and cis-(Cl,Cl)-[Ru^II(FT)Cl₂(NO)](PF₆): promising candidates for NO release in the NIR region†

Joelle Akl,^a Isabelle Sasaki,^a Pascal G. Lacroix,^a Vincent Hugues,^b Patricia Vicendo,^c Mathilde Bocé,^ad Sonia Mallet-Ladeira,^a Mireille Blanchard-Desce*^b and Isabelle Malfant*^a

Author affiliations

* Corresponding authors

^a Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, F-31077 Toulouse, France
E-mail: isabelle.malfant@lcc-toulouse.fr

^b Institute of Molecular Sciences (CNRS UMR 5255), 351 cours de la libération 33405, Talence Cedex, France

^c Laboratoire des Interactions Moléculaires et de la Réactivité Chimique et Photochimique, Université Paul Sabatier 118 route de Narbonne, F-31062 Toulouse, France

^d Institut de Pharmacologie et de Biologie Structurale, 205 route de Narbonne, F-31077 Toulouse, France

Abstract

cis- and trans-(Cl,Cl)-[Ru^II(FT)Cl₂(NO)](PF₆) complexes show efficient NO photodelivery upon two-photon excitation in the NIR region. Moreover, cytotoxicity and phototoxicity studies provide evidence that these complexes are promising candidates as photoactivatable molecular tools for resection of malignancies.

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Article information

DOI: https://doi.org/10.1039/C6PP00181E
Article type: Paper
Submitted: 03 Jun 2016
Accepted: 10 Oct 2016
First published: 11 Oct 2016

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Photochem. Photobiol. Sci., 2016,15, 1484-1491

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trans- and cis-(Cl,Cl)-[Ru^II(FT)Cl₂(NO)](PF₆): promising candidates for NO release in the NIR region

J. Akl, I. Sasaki, P. G. Lacroix, V. Hugues, P. Vicendo, M. Bocé, S. Mallet-Ladeira, M. Blanchard-Desce and I. Malfant, Photochem. Photobiol. Sci., 2016, 15, 1484 DOI: 10.1039/C6PP00181E

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Photochemical & Photobiological Sciences