One-pot conversion reactions of glycosyl boranophosphates into glycosyl phosphate derivatives via acyl phosphite intermediates†
Abstract
A one-pot synthesis of glycosyl phosphates and their P-modified analogs from glycosyl boranophosphates under mild basic conditions has been conducted. 31P NMR monitoring of the reaction mixture revealed that the key intermediates of these reactions were acyl phosphites, which could not be formed from the corresponding H-phosphonate diesters.