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The asymmetric total syntheses of hedyosumin E aglycon, 7,10-epoxyhedyosminolide and ent-zedolactone A were realized, with the first two being achieved for the first time.

Graphical abstract: Asymmetric total synthesis of hedyosumin E aglycon, 7,10-epoxyhedyosminolide and ent-zedolactone A

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