Issue 42, 2016
From the journal:

Organic & Biomolecular Chemistry

Novel and efficient transformation of enamides into α-acyloxy ketones via an acyl intramolecular migration process†

Xiaoqiang Zhou, ORCID logo a   Haojie Ma,a   Jinhui Cao,a   Xingxing Liua  and  Guosheng Huang*a  

* Corresponding authors

a State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Department of Chemistry, Lanzhou University, Lanzhou, China
E-mail: hgs@lzu.edu.cn
Fax: +86-931-8912582

Abstract

Hydrogen peroxide and anhydride mediated transformation of enamides to afford substituted α-acyloxy ketones is described. This transition-metal-free cascade reaction has a broad substrate scope and high efficiency. The acyl intramolecular migration procedure successfully achieved this acyloxylation process under mild conditions and increased the atom efficiency.

Graphical abstract: Novel and efficient transformation of enamides into α-acyloxy ketones via an acyl intramolecular migration process

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Article information

DOI
https://doi.org/10.1039/C6OB02002J
Article type
Paper
Submitted
12 Sep 2016
Accepted
30 Sep 2016
First published
30 Sep 2016

Org. Biomol. Chem., 2016,14, 10070-10073

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Novel and efficient transformation of enamides into α-acyloxy ketones via an acyl intramolecular migration process

X. Zhou, H. Ma, J. Cao, X. Liu and G. Huang, Org. Biomol. Chem., 2016, 14, 10070 DOI: 10.1039/C6OB02002J

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