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Issue 38, 2016
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Stabilized pyrrolyl iodonium salts and metal-free oxidative cross-coupling

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Abstract

Pyrrole–aryl derivatives are important due to their unique biological activities in medicinal chemistry. We now report a new oxidative biaryl coupling for pyrroles and indoles toward various arenes using a hypervalent iodine reagent and an appropriate stabilizer for pyrrolyl iodonium intermediates. The reactions readily provide a variety of desired coupling products in good yields.

Graphical abstract: Stabilized pyrrolyl iodonium salts and metal-free oxidative cross-coupling

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Article information


Submitted
13 Aug 2016
Accepted
06 Sep 2016
First published
12 Sep 2016

Org. Biomol. Chem., 2016,14, 8947-8951
Article type
Communication

Stabilized pyrrolyl iodonium salts and metal-free oxidative cross-coupling

K. Morimoto, Y. Ohnishi, D. Koseki, A. Nakamura, T. Dohi and Y. Kita, Org. Biomol. Chem., 2016, 14, 8947
DOI: 10.1039/C6OB01764A

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