Issue 45, 2016
From the journal:

Organic & Biomolecular Chemistry

Synthesis of HIV-1 capsid protein assembly inhibitor (CAP-1) and its analogues based on a biomass approach†

Leonid V. Romashova  and  Valentine P. Ananikov*ab  

* Corresponding authors

a Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prospect 47, 119991 Moscow, Russia
E-mail: val@ioc.ac.ru

b Saint Petersburg State University, Stary Petergof, Saint Petersburg, Russia

Abstract

A biomass-derived platform chemical was utilized to access a demanded pharmaceutical substance with anti-HIV activity (HIV, human immunodeficiency virus) and a variety of structural analogues. Step economy in the synthesis of the drug core (single stage from cellulose) is studied including flexible variability of four structural units. The first synthesis and X-ray structure of the inhibitor of HIV-1 capsid protein assembly (CAP-1) is described.

Graphical abstract: Synthesis of HIV-1 capsid protein assembly inhibitor (CAP-1) and its analogues based on a biomass approach

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Article information

DOI
https://doi.org/10.1039/C6OB01731B
Article type
Paper
Submitted
10 Aug 2016
Accepted
16 Sep 2016
First published
30 Sep 2016
This article is Open Access
Creative Commons BY-NC license

Org. Biomol. Chem., 2016,14, 10593-10598

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Synthesis of HIV-1 capsid protein assembly inhibitor (CAP-1) and its analogues based on a biomass approach

L. V. Romashov and V. P. Ananikov, Org. Biomol. Chem., 2016, 14, 10593 DOI: 10.1039/C6OB01731B

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