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A highly enantioselective asymmetric addition reaction of thioglycolates and N-Boc aldimines was promoted by a bifunctional tertiary-amine squaramide catalyst. As a result, a number of chiral N,S-acetal derivatives were efficiently synthesized with good enantioselectivities.

Graphical abstract: Asymmetric additions of thioglycolates and N-Boc aldimines catalyzed by a bifunctional tertiary-amine squaramide

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