Issue 39, 2016
From the journal:

Organic & Biomolecular Chemistry

Asymmetric additions of thioglycolates and N-Boc aldimines catalyzed by a bifunctional tertiary-amine squaramide†

Bo-Xu Feng,ab   Bin Wang*c  and  Xin Li*ab  

* Corresponding authors

a State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering, Department of Chemistry, Nankai University, Tianjin 300071, P. R. China

b Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300071, China

c Tianjin Key Laboratory of Structure and Performance for Functional Molecule, College of Chemistry, Tianjin Normal University, Tianjin 300387, China
E-mail: xin_li@nankai.edu.cn, hxxywangb@mail.tjnu.edu.cn

Abstract

A highly enantioselective asymmetric addition reaction of thioglycolates and N-Boc aldimines was promoted by a bifunctional tertiary-amine squaramide catalyst. As a result, a number of chiral N,S-acetal derivatives were efficiently synthesized with good enantioselectivities.

Graphical abstract: Asymmetric additions of thioglycolates and N-Boc aldimines catalyzed by a bifunctional tertiary-amine squaramide

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Article information

DOI
https://doi.org/10.1039/C6OB01645F
Article type
Communication
Submitted
01 Aug 2016
Accepted
16 Aug 2016
First published
16 Aug 2016

Org. Biomol. Chem., 2016,14, 9206-9209

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Asymmetric additions of thioglycolates and N-Boc aldimines catalyzed by a bifunctional tertiary-amine squaramide

B. Feng, B. Wang and X. Li, Org. Biomol. Chem., 2016, 14, 9206 DOI: 10.1039/C6OB01645F

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