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Issue 33, 2016
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Synthesis of “neoprofen”, a rigidified analogue of ibuprofen, exemplifying synthetic methodology for altering the 3-D topology of pharmaceutical substances

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Abstract

3,3-Dimethylcyclopentanes (neopentylenes) are ubiquitous in Nature but largely absent from synthetic pharmaceutical libraries. Neopentylenes define a hydrophobic and rigid 3-D topology with distinct molecular pharmacology, as exemplified here with two neopentylene-fused analogues of the synthetic anti-inflammatory drug, ibuprofen.

Graphical abstract: Synthesis of “neoprofen”, a rigidified analogue of ibuprofen, exemplifying synthetic methodology for altering the 3-D topology of pharmaceutical substances

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Publication details

The article was received on 22 Jun 2016, accepted on 01 Aug 2016 and first published on 01 Aug 2016


Article type: Communication
DOI: 10.1039/C6OB01351A
Citation: Org. Biomol. Chem., 2016,14, 7855-7858
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    Synthesis of “neoprofen”, a rigidified analogue of ibuprofen, exemplifying synthetic methodology for altering the 3-D topology of pharmaceutical substances

    R. R. Ramsubhag, C. L. Massaro, C. M. Dadich, A. J. Janeczek, T. T. Hoang, E. A. Mazzio, S. Eyunni, K. F. A. Soliman and G. B. Dudley, Org. Biomol. Chem., 2016, 14, 7855
    DOI: 10.1039/C6OB01351A

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