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Issue 33, 2016
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Synthesis of “neoprofen”, a rigidified analogue of ibuprofen, exemplifying synthetic methodology for altering the 3-D topology of pharmaceutical substances

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Abstract

3,3-Dimethylcyclopentanes (neopentylenes) are ubiquitous in Nature but largely absent from synthetic pharmaceutical libraries. Neopentylenes define a hydrophobic and rigid 3-D topology with distinct molecular pharmacology, as exemplified here with two neopentylene-fused analogues of the synthetic anti-inflammatory drug, ibuprofen.

Graphical abstract: Synthesis of “neoprofen”, a rigidified analogue of ibuprofen, exemplifying synthetic methodology for altering the 3-D topology of pharmaceutical substances

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Article information


Submitted
22 Jun 2016
Accepted
01 Aug 2016
First published
01 Aug 2016

Org. Biomol. Chem., 2016,14, 7855-7858
Article type
Communication

Synthesis of “neoprofen”, a rigidified analogue of ibuprofen, exemplifying synthetic methodology for altering the 3-D topology of pharmaceutical substances

R. R. Ramsubhag, C. L. Massaro, C. M. Dadich, A. J. Janeczek, T. T. Hoang, E. A. Mazzio, S. Eyunni, K. F. A. Soliman and G. B. Dudley, Org. Biomol. Chem., 2016, 14, 7855
DOI: 10.1039/C6OB01351A

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