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Issue 27, 2016
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Efficient synthesis of fluorescent alkynyl C-nucleosides via Sonogashira coupling for the preparation of DNA-based polyfluorophores

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Abstract

A facile and general procedure for the preparation of alkynyl C-nucleosides with varied fluorophores is presented. Sonogashira coupling was used as a key reaction to conjugate the dyes to an easily accessible ethynyl functionalized deoxyribose derivative. The new C-nucleosides were used for the preparation of DNA-based polyfluorophores.

Graphical abstract: Efficient synthesis of fluorescent alkynyl C-nucleosides via Sonogashira coupling for the preparation of DNA-based polyfluorophores

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Article information


Submitted
02 Jun 2016
Accepted
06 Jun 2016
First published
10 Jun 2016

Org. Biomol. Chem., 2016,14, 6407-6412
Article type
Communication

Efficient synthesis of fluorescent alkynyl C-nucleosides via Sonogashira coupling for the preparation of DNA-based polyfluorophores

D. K. Kölmel, L. J. Barandun and E. T. Kool, Org. Biomol. Chem., 2016, 14, 6407
DOI: 10.1039/C6OB01199C

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