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Issue 29, 2016
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A metal-catalyzed enyne-cyclization step for the synthesis of bi- and tricyclic scaffolds amenable to molecular library production

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Abstract

A facile metal-catalyzed diversification step for the synthesis of novel bi- and tricyclic scaffolds from enyne substrates is reported in this study. From a single starting material, topologically diverse scaffolds for library synthesis can be generated and decorated in a few steps. The methodology was used to produce a library of 490 compounds within the European Lead Factory (ELF) Consortium.

Graphical abstract: A metal-catalyzed enyne-cyclization step for the synthesis of bi- and tricyclic scaffolds amenable to molecular library production

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Supplementary files

Article information


Submitted
26 May 2016
Accepted
24 Jun 2016
First published
24 Jun 2016

This article is Open Access

Org. Biomol. Chem., 2016,14, 6947-6950
Article type
Communication

A metal-catalyzed enyne-cyclization step for the synthesis of bi- and tricyclic scaffolds amenable to molecular library production

P. Wu, M. Å. Petersen, A. E. Cohrt, R. Petersen, R. Morgentin, H. Lemoine, C. Roche, A. Willaume, M. H. Clausen and T. E. Nielsen, Org. Biomol. Chem., 2016, 14, 6947
DOI: 10.1039/C6OB01148A

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