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Issue 32, 2016
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Iodine-mediated synthesis of heterocycles via electrophilic cyclization of alkynes

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Abstract

Iodine has been recognized as an efficient, non-toxic, readily available and easy-to-handle electrophilic reagent to favour halocyclization reactions for the synthesis of novel iodofunctionalized heterocyclic molecules that serve as versatile intermediates in synthetic organic chemistry. This review presents numerous useful methodologies for the synthesis of O, N, S, and Se-heterocycles through electrophilic cyclization via the attack of an electrophile on the C(sp) bond of alkynes. The cyclization proceeds under mild reaction conditions and tolerates a wide variety of functional groups.

Graphical abstract: Iodine-mediated synthesis of heterocycles via electrophilic cyclization of alkynes

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Article information


Submitted
14 May 2016
Accepted
24 Jun 2016
First published
28 Jun 2016

Org. Biomol. Chem., 2016,14, 7639-7653
Article type
Review Article

Iodine-mediated synthesis of heterocycles via electrophilic cyclization of alkynes

T. Aggarwal, S. Kumar and A. K. Verma, Org. Biomol. Chem., 2016, 14, 7639
DOI: 10.1039/C6OB01054G

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