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Issue 32, 2016
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Iodine-mediated synthesis of heterocycles via electrophilic cyclization of alkynes

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Abstract

Iodine has been recognized as an efficient, non-toxic, readily available and easy-to-handle electrophilic reagent to favour halocyclization reactions for the synthesis of novel iodofunctionalized heterocyclic molecules that serve as versatile intermediates in synthetic organic chemistry. This review presents numerous useful methodologies for the synthesis of O, N, S, and Se-heterocycles through electrophilic cyclization via the attack of an electrophile on the C(sp) bond of alkynes. The cyclization proceeds under mild reaction conditions and tolerates a wide variety of functional groups.

Graphical abstract: Iodine-mediated synthesis of heterocycles via electrophilic cyclization of alkynes

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Publication details

The article was received on 14 May 2016, accepted on 24 Jun 2016 and first published on 28 Jun 2016


Article type: Review Article
DOI: 10.1039/C6OB01054G
Org. Biomol. Chem., 2016,14, 7639-7653

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    Iodine-mediated synthesis of heterocycles via electrophilic cyclization of alkynes

    T. Aggarwal, S. Kumar and A. K. Verma, Org. Biomol. Chem., 2016, 14, 7639
    DOI: 10.1039/C6OB01054G

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