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Issue 26, 2016
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Dual modification of biomolecules

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With the advent of novel bioorthogonal reactions and “click” chemistry, an increasing number of strategies for the single labelling of proteins and oligonucleotides have emerged. Whilst several methods exist for the site-selective introduction of a single chemical moiety, site-selective and bioorthogonal dual modification of biomolecules remains a challenge. The introduction of multiple modules enables a plethora of permutations and combinations and can generate a variety of bioconjuguates with many potential applications. From de novo approaches on oligomers to the post-translational functionalisation of proteins, this review will highlight the main strategies to dually modify biomolecules.

Graphical abstract: Dual modification of biomolecules

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Article information

09 May 2016
02 Jun 2016
First published
02 Jun 2016

Org. Biomol. Chem., 2016,14, 6165-6178
Article type
Review Article
Author version available

Dual modification of biomolecules

A. Maruani, D. A. Richards and V. Chudasama, Org. Biomol. Chem., 2016, 14, 6165
DOI: 10.1039/C6OB01010E

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