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Issue 26, 2016
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Dual modification of biomolecules

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With the advent of novel bioorthogonal reactions and “click” chemistry, an increasing number of strategies for the single labelling of proteins and oligonucleotides have emerged. Whilst several methods exist for the site-selective introduction of a single chemical moiety, site-selective and bioorthogonal dual modification of biomolecules remains a challenge. The introduction of multiple modules enables a plethora of permutations and combinations and can generate a variety of bioconjuguates with many potential applications. From de novo approaches on oligomers to the post-translational functionalisation of proteins, this review will highlight the main strategies to dually modify biomolecules.

Graphical abstract: Dual modification of biomolecules

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The article was received on 09 May 2016, accepted on 02 Jun 2016 and first published on 02 Jun 2016

Article type: Review Article
DOI: 10.1039/C6OB01010E
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Citation: Org. Biomol. Chem., 2016,14, 6165-6178

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    Dual modification of biomolecules

    A. Maruani, D. A. Richards and V. Chudasama, Org. Biomol. Chem., 2016, 14, 6165
    DOI: 10.1039/C6OB01010E

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