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Issue 23, 2016
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Base-catalyzed controllable reaction of 3-ylideneoxindoles with O-Boc hydroxycarbamates for the synthesis of amidoacrylates and spiroaziridine oxindoles

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Abstract

A base-catalyzed divergent reaction of 3-ylideneoxindoles with O-Boc hydroxycarbamates has been developed to provide efficient access to various amidoacrylates and spiroaziridine oxindoles with generally high yields, which should be potentially useful in drug discovery.

Graphical abstract: Base-catalyzed controllable reaction of 3-ylideneoxindoles with O-Boc hydroxycarbamates for the synthesis of amidoacrylates and spiroaziridine oxindoles

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Article information


Submitted
26 Apr 2016
Accepted
16 May 2016
First published
17 May 2016

Org. Biomol. Chem., 2016,14, 5224-5228
Article type
Communication

Base-catalyzed controllable reaction of 3-ylideneoxindoles with O-Boc hydroxycarbamates for the synthesis of amidoacrylates and spiroaziridine oxindoles

Y. Liu, S. Duan, R. Zhang, Y. Liu, J. Chen and W. Xiao, Org. Biomol. Chem., 2016, 14, 5224
DOI: 10.1039/C6OB00891G

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