Issue 25, 2016
From the journal:

Organic & Biomolecular Chemistry

Total synthesis of desoxycyclomarin C and the cyclomarazines A and B†

Philipp Barbiea  and  Uli Kazmaier*a  

* Corresponding authors

a Institute of Organic Chemistry, Saarland University, P.O. Box 151150, 66041 Saarbrücken, Germany
E-mail: u.kazmaier@mx.uni-saarland.de

Abstract

Removing the β-hydroxy group from the prenylated tryptophan moiety of cyclomarins simplifies the synthesis of these interesting natural products significantly, without having a noteworthy effect on the anti-tuberculosis activity of the cyclomarins. In contrast, cyclomarazines did not show biological activity.

Graphical abstract: Total synthesis of desoxycyclomarin C and the cyclomarazines A and B

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Article information

DOI
https://doi.org/10.1039/C6OB00801A
Article type
Paper
Submitted
14 Apr 2016
Accepted
19 May 2016
First published
31 May 2016

Org. Biomol. Chem., 2016,14, 6055-6064

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Total synthesis of desoxycyclomarin C and the cyclomarazines A and B

P. Barbie and U. Kazmaier, Org. Biomol. Chem., 2016, 14, 6055 DOI: 10.1039/C6OB00801A

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