New (green) methodology for efficient hydrazine cleavage

Abstract

An efficient method for removal of the hydrazine group from (hetero)aromatic substrates has been developed. It can be realized both on a solid support and in solution by synthesis employing a low concentration solution of trimethylsilanolate in tetrahydrofuran or N,N-dimethylformamide. For water-soluble substrates, the reaction can be performed in water, highlighting the eco-friendly attributes of this methodology.