Santosh J. Gharpure and Santosh K. Nanda
Org. Biomol. Chem., 2016,14, 5586-5590
DOI:
10.1039/C6OB00501B,
Communication
An inter- as well as intra-molecular thia-Pictet–Spengler cyclization of N-tethered thiols and vinylogous thiocarbonates is described for the stereoselective synthesis of N-fused thiazinoindole derivatives. The strategy is extended to one-pot, sequential Friedel–Crafts alkylation – Pictet–Spengler cyclization and the synthesis of thiazino-oxepino-indole.
![Graphical abstract: Stereoselective synthesis of thiazino[4,3-a]indoles using the thia-Pictet–Spengler reaction of indoles bearing N-tethered thiols and vinylogous thiocarbonates](/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=C6OB00501B "Graphical abstract")
