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Issue 16, 2016
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Acetylpyrene-labelled 7-methylguanine nucleotides: unusual fluorescence properties and application to decapping scavenger activity monitoring

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Abstract

7-Methylguanosine (m7G) nucleotides labelled with acetylpyrene (AcPy) were synthesized as fluorescent mRNA 5′ end (cap) analogues. The unique fluorescent properties of m7G–AcPy conjugates, different from G–AcPy, can be applied to studying various mRNA cap-related processes including the evaluation of putative inhibitors of DcpS enzyme—a therapeutic target in neuromuscular diseases.

Graphical abstract: Acetylpyrene-labelled 7-methylguanine nucleotides: unusual fluorescence properties and application to decapping scavenger activity monitoring

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Supplementary files

Article information


Submitted
23 Feb 2016
Accepted
08 Mar 2016
First published
08 Mar 2016

Org. Biomol. Chem., 2016,14, 3863-3868
Article type
Communication

Acetylpyrene-labelled 7-methylguanine nucleotides: unusual fluorescence properties and application to decapping scavenger activity monitoring

R. Kasprzyk, J. Kowalska, Z. Wieczorek, M. Szabelski, R. Stolarski and J. Jemielity, Org. Biomol. Chem., 2016, 14, 3863
DOI: 10.1039/C6OB00419A

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