Ying-Chieh Wong and Ying-Yeung Yeung
Org. Biomol. Chem., 2016,14, 3202-3206
DOI:
10.1039/C6OB00311G,
Communication
We developed a simple and efficient method to construct a variety of α-ester bromolactones in good to excellent yields with high diastereoselectivies. The protocol uses readily prepared malonate ester derivatives as substrates, water as an additive and inexpensive N-bromosuccinimide as the halogen source; no catalyst or toxic additive is required. The resulting substituted bromolactones are the fundamental units of many useful molecules.
