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Issue 24, 2016
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Ruthenium photoredox-triggered phospholipid membrane formation

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As more methodologies for generating and manipulating biomimetic cellular systems are developed, opportunities arise for combining different methods to create more complex synthetic biological constructs. This necessitates an increasing need for tools to selectively trigger individual methodologies. Here we demonstrate ruthenium tris-bipyridine mediated photoredox triggering of the copper catalyzed alkyne azide cycloaddition reaction (CuAAC), resulting in the synthesis of biomimetic phospholipids in situ, and subsequent membrane assembly. The use of a ruthenium–copper electron transport chain to trigger phospholipid assembly opens up future opportunities for spatiotemporal synthesis of membranes.

Graphical abstract: Ruthenium photoredox-triggered phospholipid membrane formation

  • This article is part of the themed collection: New Talent
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Article information

03 Feb 2016
22 Feb 2016
First published
22 Feb 2016

Org. Biomol. Chem., 2016,14, 5555-5558
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Ruthenium photoredox-triggered phospholipid membrane formation

M. D. Hardy, D. Konetski, C. N. Bowman and N. K. Devaraj, Org. Biomol. Chem., 2016, 14, 5555
DOI: 10.1039/C6OB00290K

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