Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 12, 2016
Previous Article Next Article

Aminoquinoline-assisted vinylic C–H arylation of unsubstituted acrylamide for the selective synthesis of Z olefins

Author affiliations

Abstract

A method for Pd-catalyzed, aminoquinoline-directed arylation of vinylic C–H bonds with aryl iodides has been developed. This reaction represents a rare example of Pd-catalyzed vinylic C–H functionalization of unsubstituted acrylamide, allowing for the highly regio- and stereoselective preparation of Z-olefins. High tolerance to functional groups is observed with good yields and excellent selectivity. It offers a complementary synthetic method to traditional pathways for Z-olefins.

Graphical abstract: Aminoquinoline-assisted vinylic C–H arylation of unsubstituted acrylamide for the selective synthesis of Z olefins

Back to tab navigation

Supplementary files

Article information


Submitted
19 Jan 2016
Accepted
18 Feb 2016
First published
18 Feb 2016

Org. Biomol. Chem., 2016,14, 3298-3306
Article type
Paper
Author version available

Aminoquinoline-assisted vinylic C–H arylation of unsubstituted acrylamide for the selective synthesis of Z olefins

X. Cheng, Z. Chen, Y. Gao, F. Xue and C. Jiang, Org. Biomol. Chem., 2016, 14, 3298
DOI: 10.1039/C6OB00164E

Social activity

Search articles by author

Spotlight

Advertisements