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Issue 11, 2016
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Synthesis and evaluation of membrane permeabilizing properties of cationic amphiphiles derived from the disaccharide trehalose

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Abstract

Cationic amphiphiles derived from trehalose have been synthesized; trehalose analogues substituted with n-pentyl or n-hexyl ethers exhibited membrane disrupting activities against clinically important Gram positive and Gram negative bacteria and fungi. Our results demonstrate that trehalose is a useful disaccharide scaffold for the development of broad-spectrum antimicrobial and antifungal agents.

Graphical abstract: Synthesis and evaluation of membrane permeabilizing properties of cationic amphiphiles derived from the disaccharide trehalose

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Supplementary files

Article information


Submitted
07 Jan 2016
Accepted
21 Jan 2016
First published
21 Jan 2016

Org. Biomol. Chem., 2016,14, 3012-3015
Article type
Communication

Synthesis and evaluation of membrane permeabilizing properties of cationic amphiphiles derived from the disaccharide trehalose

P. Shaul, R. I. Benhamou, I. M. Herzog, S. Louzoun Zada, Y. Ebenstein and M. Fridman, Org. Biomol. Chem., 2016, 14, 3012 DOI: 10.1039/C6OB00031B

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