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Issue 7, 2016
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The total synthesis of calcium atorvastatin

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Abstract

A practical and convergent asymmetric route to calcium atorvastatin (1) is reported. The synthesis of calcium atorvastatin (1) was performed using the remote 1,5-anti asymmetric induction in the boron-mediated aldol reaction of β-alkoxy methylketone (4) with pyrrolic aldehyde (3) as a key step. Calcium atorvastatin was obtained from aldehyde (3) after 6 steps, with a 41% overall yield.

Graphical abstract: The total synthesis of calcium atorvastatin

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Article information


Submitted
12 Dec 2015
Accepted
29 Dec 2015
First published
13 Jan 2016

Org. Biomol. Chem., 2016,14, 2291-2296
Article type
Paper
Author version available

The total synthesis of calcium atorvastatin

L. C. Dias, A. S. Vieira and E. J. Barreiro, Org. Biomol. Chem., 2016, 14, 2291
DOI: 10.1039/C5OB02546J

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