Jump to main content
Jump to site search

Issue 5, 2016
Previous Article Next Article

Room-temperature cobalt-catalyzed arylation of aromatic acids: overriding the ortho-selectivity via the oxidative assembly of carboxylate and aryl titanate reagents using oxygen

Author affiliations

Abstract

A room temperature phosphine or NHC ligand-free cobalt-catalyzed arylation of (hetero)aromatic acids has been developed. It involves an oxidative cross-coupling between carboxylate and aryl titanate reagents using oxygen as an oxidant, and the arylation at the position ortho, meta and para to the carboxylic acid group could all be achieved. As application, various (hetero)aromatic acids including xenalipin, tafamidis and the key intermediate for a cardioprotective compound have been efficiently synthesized.

Graphical abstract: Room-temperature cobalt-catalyzed arylation of aromatic acids: overriding the ortho-selectivity via the oxidative assembly of carboxylate and aryl titanate reagents using oxygen

Back to tab navigation

Supplementary files

Publication details

The article was received on 07 Dec 2015, accepted on 22 Dec 2015 and first published on 22 Dec 2015


Article type: Paper
DOI: 10.1039/C5OB02496J
Citation: Org. Biomol. Chem., 2016,14, 1593-1598
  •   Request permissions

    Room-temperature cobalt-catalyzed arylation of aromatic acids: overriding the ortho-selectivity via the oxidative assembly of carboxylate and aryl titanate reagents using oxygen

    K. Liu, R. Zhang and X. Duan, Org. Biomol. Chem., 2016, 14, 1593
    DOI: 10.1039/C5OB02496J

Search articles by author

Spotlight

Advertisements