Jump to main content
Jump to site search

Issue 5, 2016
Previous Article Next Article

Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay

Author affiliations

Abstract

During efforts to prepare the known compound NMDI1, a new tetracyclic compound, called VG1, was prepared in six steps. This compound was found to have good activity as an inhibitor of nonsense-mediated mRNA decay.

Graphical abstract: Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay

Back to tab navigation

Supplementary files

Article information


Submitted
04 Dec 2015
Accepted
24 Dec 2015
First published
24 Dec 2015

This article is Open Access

Org. Biomol. Chem., 2016,14, 1559-1563
Article type
Communication
Author version available

Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay

V. J. B. Gotham, M. C. Hobbs, R. Burgin, D. Turton, C. Smythe and I. Coldham, Org. Biomol. Chem., 2016, 14, 1559
DOI: 10.1039/C5OB02482J

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements