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An efficient ligand-free Pd(OAc)2-catalyzed selective arylation of pyridine N-oxides using potassium (hetero)aryltrifluoroborates as coupling partners via C–H bond activation was achieved in the presence of TBAI. This approach has a broad substrate scope and shows moderate to high yields.

Graphical abstract: Palladium-catalyzed direct C–H arylation of pyridine N-oxides with potassium aryl- and heteroaryltrifluoroborates

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