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Issue 3, 2016
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An economical synthesis of substituted quinoline-2-carboxylates through the potassium persulfate-mediated cross-dehydrogenative coupling of N-aryl glycine derivatives with olefins

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Abstract

A practical and economical K2S2O8-mediated oxidative cross-dehydrogenative coupling of N-aryl glycine derivatives with olefins has been established, affording structurally diverse quinoline-2-carboxylates in good to high efficiency. The low cost, negligible toxicity, and ease of handling of K2S2O8 combined with the absence of hazardous byproducts and the easy workup consisting of simple filtration are attractive based on economic and environmental factors.

Graphical abstract: An economical synthesis of substituted quinoline-2-carboxylates through the potassium persulfate-mediated cross-dehydrogenative coupling of N-aryl glycine derivatives with olefins

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Publication details

The article was received on 27 Oct 2015, accepted on 29 Nov 2015 and first published on 01 Dec 2015


Article type: Paper
DOI: 10.1039/C5OB02216A
Citation: Org. Biomol. Chem., 2016,14, 1147-1152

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    An economical synthesis of substituted quinoline-2-carboxylates through the potassium persulfate-mediated cross-dehydrogenative coupling of N-aryl glycine derivatives with olefins

    G. Liu, J. Qian, J. Hua, F. Cai, X. Li and L. Liu, Org. Biomol. Chem., 2016, 14, 1147
    DOI: 10.1039/C5OB02216A

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