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Issue 3, 2016
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An economical synthesis of substituted quinoline-2-carboxylates through the potassium persulfate-mediated cross-dehydrogenative coupling of N-aryl glycine derivatives with olefins

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Abstract

A practical and economical K2S2O8-mediated oxidative cross-dehydrogenative coupling of N-aryl glycine derivatives with olefins has been established, affording structurally diverse quinoline-2-carboxylates in good to high efficiency. The low cost, negligible toxicity, and ease of handling of K2S2O8 combined with the absence of hazardous byproducts and the easy workup consisting of simple filtration are attractive based on economic and environmental factors.

Graphical abstract: An economical synthesis of substituted quinoline-2-carboxylates through the potassium persulfate-mediated cross-dehydrogenative coupling of N-aryl glycine derivatives with olefins

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Article information


Submitted
27 Oct 2015
Accepted
29 Nov 2015
First published
01 Dec 2015

Org. Biomol. Chem., 2016,14, 1147-1152
Article type
Paper

An economical synthesis of substituted quinoline-2-carboxylates through the potassium persulfate-mediated cross-dehydrogenative coupling of N-aryl glycine derivatives with olefins

G. Liu, J. Qian, J. Hua, F. Cai, X. Li and L. Liu, Org. Biomol. Chem., 2016, 14, 1147
DOI: 10.1039/C5OB02216A

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