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Issue 24, 2016
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Lewis acid-promoted [2 + 2] cycloadditions of alkenes with aryl ketenes

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Abstract

A method for the [2 + 2] cycloaddition of aryl ketenes and alkenes is presented. The process involves the in situ generation of a ketene in the presence of a Lewis acid. The utility of products is demonstrated towards the synthesis of a common scaffold found in several natural product families.

Graphical abstract: Lewis acid-promoted [2 + 2] cycloadditions of alkenes with aryl ketenes

  • This article is part of the themed collection: New Talent
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Article information


Submitted
02 Sep 2015
Accepted
22 Sep 2015
First published
30 Sep 2015

Org. Biomol. Chem., 2016,14, 5477-5480
Article type
Communication

Lewis acid-promoted [2 + 2] cycloadditions of alkenes with aryl ketenes

E. M. Rigsbee, C. Zhou, C. M. Rasik, A. Z. Spitz, A. J. Nichols and M. K. Brown, Org. Biomol. Chem., 2016, 14, 5477
DOI: 10.1039/C5OB01837D

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