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Issue 44, 2016
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Three-minute synthesis of sp3 nanocrystalline carbon dots as non-toxic fluorescent platforms for intracellular delivery

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Abstract

A one-pot, three-minute, gram-scale synthesis of novel sp3-nanocrystalline, water-soluble, and fluorescent carbon dots (FCDs), from simple and cheap sugar starting materials is described. Mechanism studies showed that NH2-FCD formation proceeds via a crucial imine intermediate derived from reaction between a sugar hemiacetal and an amine. Moreover, we successfully demonstrate the utility of lactose functionalized FCDots (Lac-FCDots) as non-toxic fluorescent intracellular delivery vehicles.

Graphical abstract: Three-minute synthesis of sp3 nanocrystalline carbon dots as non-toxic fluorescent platforms for intracellular delivery

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Publication details

The article was received on 16 Sep 2016, accepted on 20 Oct 2016 and first published on 21 Oct 2016


Article type: Communication
DOI: 10.1039/C6NR07336K
Nanoscale, 2016,8, 18630-18634
  • Open access: Creative Commons BY license
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    Three-minute synthesis of sp3 nanocrystalline carbon dots as non-toxic fluorescent platforms for intracellular delivery

    S. A. Hill, David. Benito-Alifonso, D. J. Morgan, S. A. Davis, M. Berry and M. C. Galan, Nanoscale, 2016, 8, 18630
    DOI: 10.1039/C6NR07336K

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