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Issue 43, 2016
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A field effect glucose sensor with a nanostructured amorphous In–Ga–Zn–O network

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Amorphous indium gallium zinc oxide (IGZO) field effect transistors (FETs) are a promising technology for a wide range of electronic applications. Herein, we fabricated and characterized FETs with a nanostructured IGZO network as a sensing transducer. The IGZO was patterned using colloidal lithography and electrohydrodynamic printing, where an 8 μm wide nanostructured close-packed hexagonal IGZO network was obtained. Electrical characterization of the nanostructured IGZO network FET demonstrated a drain–source current on–off ratio of 6.1 × 103 and effective electron mobilities of 3.6 cm2 V−1 s−1. The nanostructured IGZO network was functionalized by aminosilane groups with cross-linked glucose oxidase. The devices demonstrated a decrease in drain–source conductance and a more positive VON with increasing glucose concentration. These changes are ascribed to the acceptor-like surface states associated with positively charged aminosilane groups attached to the nanostructured IGZO surface. Continuous monitoring of the drain–source current indicates a stepwise and fully reversible response to glucose concentrations with a short response time. The specific catalytic reaction between the GOx enzyme and glucose eliminates interference from acetaminophen/ascorbic acid. We demonstrate that nanostructured IGZO FETs have improved sensitivity compared to non-nanostructured IGZO for sensing glucose and can be potentially extended to other biosensor technologies.

Graphical abstract: A field effect glucose sensor with a nanostructured amorphous In–Ga–Zn–O network

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Publication details

The article was received on 27 Jun 2016, accepted on 06 Oct 2016 and first published on 07 Oct 2016

Article type: Paper
DOI: 10.1039/C6NR05134K
Citation: Nanoscale, 2016,8, 18469-18475

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    A field effect glucose sensor with a nanostructured amorphous In–Ga–Zn–O network

    X. Du, Y. Li and G. S. Herman, Nanoscale, 2016, 8, 18469
    DOI: 10.1039/C6NR05134K

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