Issue 28, 2016
From the journal:

Nanoscale

Multifunctional gold nanocomposites designed for targeted CT/MR/optical trimodal imaging of human non-small cell lung cancer cells†

Jingwen Chen,‡a   Yingqi Sun,‡a   Qian Chen,‡b   Le Wang,c   Suhe Wang,d   Yun Tang,*e   Xiangyang Shi*bf  and  Han Wang*ag  

* Corresponding authors

a Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, People's Republic of China
E-mail: 13564112852@163.com

b State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai 201620, People's Republic of China

c Department of Radiology, Yueyang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200437, People's Republic of China

d Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan 48109-5648, USA

e Department of Chemistry, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), Fudan University, Shanghai 200433, People's Republic of China
E-mail: yuntang@fudan.edu.cn

f College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, People's Republic of China
E-mail: xshi@dhu.edu.cn

g National Engineering Research Center for Nanotechnology, Shanghai 200241, People's Republic of China
E-mail: 13564112852@163.com

Abstract

Multifunctional gold nanocomposites, which were designed as dendrimer-entrapped gold nanoparticles functionalized with gadolinium, cyanine dye (Cy5.5), and folic acid, were synthesized to be used as the first dendrimer-based clinical nanoprobes for targeted X-ray computed tomography/magnetic resonance/optical trimodal imaging in vitro and in vivo of human non-small cell cancer cells.

Graphical abstract: Multifunctional gold nanocomposites designed for targeted CT/MR/optical trimodal imaging of human non-small cell lung cancer cells

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Article information

DOI
https://doi.org/10.1039/C6NR03143A
Article type
Communication
Submitted
17 Apr 2016
Accepted
22 Jun 2016
First published
24 Jun 2016

Nanoscale, 2016,8, 13568-13573

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Multifunctional gold nanocomposites designed for targeted CT/MR/optical trimodal imaging of human non-small cell lung cancer cells

J. Chen, Y. Sun, Q. Chen, L. Wang, S. Wang, Y. Tang, X. Shi and H. Wang, Nanoscale, 2016, 8, 13568 DOI: 10.1039/C6NR03143A

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