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Issue 23, 2016
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Magnetically-responsive silica–gold nanobowls for targeted delivery and SERS-based sensing

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Abstract

Composite colloidal structures with multi-functional properties have wide applications in targeted delivery of therapeutics and imaging contrast molecules and high-throughput molecular bio-sensing. We have constructed a multifunctional composite magnetic nanobowl using the bottom-up approach on an asymmetric silica/polystyrene Janus template consisting of a silica shell around a partially exposed polystyrene core. The nanobowl consists of a silica bowl and a gold exterior shell with iron oxide magnetic nanoparticles sandwiched between the silica and gold shells. The nanobowls were characterized by electron microscopy, atomic force microscopy, magnetometry, vis-NIR and FTIR spectroscopy. Magnetically vectored transport of these nanobowls was ascertained by time-lapsed imaging of their flow in fluid through a porous hydrogel under a defined magnetic field. These magnetically-responsive nanobowls show distinct surface enhanced Raman spectroscopy (SERS) imaging capability. The PEGylated magnetically-responsive nanobowls show size-dependent cellular uptake in vitro.

Graphical abstract: Magnetically-responsive silica–gold nanobowls for targeted delivery and SERS-based sensing

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Supplementary files

Article information


Submitted
24 Mar 2016
Accepted
30 Apr 2016
First published
03 May 2016

Nanoscale, 2016,8, 11840-11850
Article type
Paper

Magnetically-responsive silica–gold nanobowls for targeted delivery and SERS-based sensing

A. H. Mo, P. B. Landon, K. S. Gomez, H. Kang, J. Lee, C. Zhang, W. Janetanakit, V. Sant, T. Lu, D. A. Colburn, S. Akkiraju, S. Dossou, Y. Cao, K. Lee, S. Varghese, G. Glinsky and R. Lal, Nanoscale, 2016, 8, 11840
DOI: 10.1039/C6NR02445A

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