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Issue 18, 2016
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Suppressing the cytotoxicity of CuO nanoparticles by uptake of curcumin/BSA particles

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Abstract

The adverse effects of metal-based nanoparticles on human beings and the environment have received extensive attention recently. It is urgently required to develop a simple and effective method to suppress the toxicity of metal-based nanomaterials. In this study, a hydrophobic antioxidant and a chelation agent curcumin (CUR) were encapsulated into bovine serum albumin (BSA) particles by a simple co-precipitation method, and followed by glutaraldehyde cross-linking. The CUR/BSA particles had an average size of 300 nm in diameter with a negatively charged surface and sustained curcumin release properties. The cellular uptake and cytotoxicity of CUR/BSA particles were followed on A549 cells, HepG2 cells and RAW264.7 cells. The CUR/BSA particles had higher intracellular accumulation and lower cytotoxicity compared with the free curcumin at the same drug concentration. The CUR/BSA particles could suppress the cytotoxicity generated by CuO nanoparticles as a result of decrease of both the intracellular reactive oxygen species (ROS) level and Cu2+ concentration, while the free curcumin did not show any obvious detoxicating effect. The detoxicating effects of CUR/BSA particles were further studied in an intratracheal instillation model in vivo, demonstrating significant reduction of toxicity and inflammatory response in rat lungs induced by CuO nanoparticles. The concept-proving study demonstrates the potential of the CUR/BSA particles in suppressing cytotoxicity of metal-based nanomaterials, which is a paramount requirement for the safe application of nanotechnology.

Graphical abstract: Suppressing the cytotoxicity of CuO nanoparticles by uptake of curcumin/BSA particles

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Article information


Submitted
16 Mar 2016
Accepted
31 Mar 2016
First published
21 Apr 2016

Nanoscale, 2016,8, 9572-9582
Article type
Paper

Suppressing the cytotoxicity of CuO nanoparticles by uptake of curcumin/BSA particles

W. Zhang, P. Jiang, Y. Chen, P. Luo, G. Li, B. Zheng, W. Chen, Z. Mao and C. Gao, Nanoscale, 2016, 8, 9572
DOI: 10.1039/C6NR02181F

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