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Issue 6, 2016
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Label-free and enzyme-free platform for the construction of advanced DNA logic devices based on the assembly of graphene oxide and DNA-templated AgNCs

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Abstract

DNA-based molecular logic computation has drawn extensive attention in bioanalysis, intelligent diagnostics of diseases and other nanotechnology areas. Herein, taking 2-to-1 and 4-to-2 encoders and a 1-to-2 decoder as model molecular logic devices, we for the first time combined the quenching ability of GO (graphene oxide) to DNA-templated AgNCs with G-quadruplex-enhanced fluorescence intensity of porphyrin dyes for the construction of label-free and enzyme-free dual-output advanced DNA molecular logic devices. Also, through the application of negative logic conversion to an XOR logic gate and combined with an INHIBIT logic gate, we also operated a label-free and enzyme-free comparator.

Graphical abstract: Label-free and enzyme-free platform for the construction of advanced DNA logic devices based on the assembly of graphene oxide and DNA-templated AgNCs

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Publication details

The article was received on 04 Jan 2016, accepted on 18 Jan 2016 and first published on 19 Jan 2016


Article type: Paper
DOI: 10.1039/C6NR00032K
Citation: Nanoscale, 2016,8, 3834-3840

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    Label-free and enzyme-free platform for the construction of advanced DNA logic devices based on the assembly of graphene oxide and DNA-templated AgNCs

    D. Fan, J. Zhu, Y. Liu, E. Wang and S. Dong, Nanoscale, 2016, 8, 3834
    DOI: 10.1039/C6NR00032K

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