Jump to main content
Jump to site search

Issue 16, 2016
Previous Article Next Article

Tunable and amplified Raman gold nanoprobes for effective tracking (TARGET): in vivo sensing and imaging

Author affiliations

Abstract

We describe the development of a highly tunable, physiologically stable, and ultra-bright Raman probe, named as TARGET (Tunable and Amplified Raman Gold Nanoprobes for Effective Tracking), for in vitro and in vivo surface-enhanced Raman scattering (SERS) applications. The TARGET structure consists of a gold core inside a larger gold shell with a tunable interstitial gap similar to a “nanorattle” structure. The combination of galvanic replacement and the seed mediated growth method was employed to load Raman reporter molecules and subsequently close the pores to prevent leaking and degradation of reporters under physiologically extreme conditions. Precise tuning of the core–shell gap width, core size, and shell thickness allows us to modulate the plasmonic effect and achieve a maximum electric-field (E-field) intensity. The interstitial gap of TARGET nanoprobes can be designed to exhibit a plasmon absorption band at 785 nm, which is in resonance with the dye absorption maximum and lies in the “tissue optical window”, resulting in ultra-bright SERS signals for in vivo studies. The results of in vivo measurements of TARGETs in laboratory mice illustrated the usefulness of these nanoprobes for medical sensing and imaging.

Graphical abstract: Tunable and amplified Raman gold nanoprobes for effective tracking (TARGET): in vivo sensing and imaging

Back to tab navigation

Supplementary files

Article information


Submitted
17 Dec 2015
Accepted
29 Mar 2016
First published
31 Mar 2016

Nanoscale, 2016,8, 8486-8494
Article type
Communication

Tunable and amplified Raman gold nanoprobes for effective tracking (TARGET): in vivo sensing and imaging

N. Gandra, H. C. Hendargo, S. J. Norton, A. M. Fales, G. M. Palmer and T. Vo-Dinh, Nanoscale, 2016, 8, 8486
DOI: 10.1039/C5NR08980H

Social activity

Search articles by author

Spotlight

Advertisements