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Issue 9, 2016
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Low generation polyamine dendrimers bearing flexible tetraethylene glycol as nanocarriers for plasmids and siRNA

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Abstract

Low G1 generation polyamine dendrimers built around programmable, flexible, and short tetraethyleneglycol branches were readily prepared in a divergent manner using a combination of orthogonal AB3 or AB5 units and highly efficient chemical transformations based on Cu(I) catalyzed alkyne–azide cycloaddition (CUAAC) and thiol–ene click reactions. The constructs showed that the G1 polyamines with only twelve and eighteen amine surface groups can successfully deliver siRNA in human cells, with transfection efficiency comparable to that of Lipofectamine 2000®. Measurements of cell viability following transfection of plasmid DNA and siRNA showed that the dendritic polyamines are less cytotoxic than Lipofectamine 2000® and are thus preferable for biological applications.

Graphical abstract: Low generation polyamine dendrimers bearing flexible tetraethylene glycol as nanocarriers for plasmids and siRNA

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Supplementary files

Article information


Submitted
29 Sep 2015
Accepted
25 Jan 2016
First published
25 Jan 2016

Nanoscale, 2016,8, 5106-5119
Article type
Paper
Author version available

Low generation polyamine dendrimers bearing flexible tetraethylene glycol as nanocarriers for plasmids and siRNA

R. Sharma, I. Zhang, T. C. Shiao, G. M. Pavan, D. Maysinger and R. Roy, Nanoscale, 2016, 8, 5106
DOI: 10.1039/C5NR06757J

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